1 injection 1 year elbow pain control ???

Hello World!

This is an exciting time of innovation that we live in. Drop me a line about any new advances you would like to share. Now some housekeeping …

If you find any of the studies even remotely useful throw them into your archive folder. If not, hit delete.

Please give me feedback on ways I can make it more useful to you.

If it is valuable to you please consider sending it on to a friend 😄 

Salivary bile acids and reflux

This study investigated the presence and concentration of bile acids in saliva and bronchoalveolar lavage fluid (BALF) in dogs with respiratory diseases (West Highland White Terriers with idiopathic pulmonary fibrosis, dogs with inflammatory airway disease, dogs with recurrent pneumonia) and healthy dogs (brachycephalic dogs, West Highland White Terriers, and other healthy dogs). The results showed that extraesophageal reflux and reflux aspiration occur in both healthy dogs and dogs with respiratory diseases. The highest concentration of bile acids was found in West Highland White Terriers with idiopathic pulmonary fibrosis, followed by brachycephalic dogs. The presence of bile acids in saliva was associated with simultaneous bile acid detection in BALF in the majority of dogs. The study suggests that measuring salivary bile acids could be a potential non-invasive biomarker for assessing extraesophageal reflux and the risk of microaspiration. The small number of dogs in some groups is a limitation of the study. 

Kouki, S, Viitanen, SJ, Koho, N, et al. Extraesophageal reflux and reflux aspiration in dogs with respiratory diseases and in healthy dogs. J Vet Intern Med. 2023; 37( 1): 268- 276. doi:10.1111/jvim.16622 

Bottom line — salivary bile acids to assess aspiration risk…

Exercise improves aging muscles

The study aimed to investigate the effects of exercise training and Yamanaka transcription factor (OKSM) expression on the epigenetic landscape and gene expression in mouse skeletal muscle. The researchers found that both exercise training and OKSM expression led to a reduction in biological aging markers in the muscle. Additionally, the study found that the gene expression signature between exercise training and OKSM expression was similar. The study also showed that the gene Myc was highly responsive to exercise and plays a role in molecular reprogramming of the transcriptome and methylome. The results suggest that Myc could be a key factor in improving muscle function and that further research is needed to understand the mechanisms of muscle molecular reprogramming and its impact on aging. 

Jones, R.G., III, Dimet-Wiley, A., Haghani, A., da Silva, F.M., Brightwell, C.R., Lim, S., Khadgi, S., Wen, Y., Dungan, C.M., Brooke, R.T., Greene, N.P., Peterson, C.A., McCarthy, J.J., Horvath, S., Watowich, S.J., Fry, C.S. and Murach, K.A. (2023), A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle. J Physiol. https://doi.org/10.1113/JP283836 Bottom line - May not always be bad news…

Bottom line — Exercise-induced muscle changes at the gene level “reprogram” them to a more youthful state

Radioactive Tin to help elbow arthritis

The study investigated the efficacy and safety of intraarticular injection of 117mSn radiocolloid (Synovetin OA®) as a treatment for dogs with low to intermediate-grade osteoarthritis of the elbow joint secondary to elbow dysplasia. The study was a longitudinal, prospective, experimental parallel group, post-test study with repeated measures and involved 44 dogs that were randomly assigned to three different dose groups. The results of the study showed positive responses to treatment in all dose groups, with the medium dose group having the highest and most durable response rate based on the canine Brief Pain Inventory scores. The results of the study support the use of 117mSn radiocolloid as a primary treatment for osteoarthritis in dogs with low to intermediate-grade osteoarthritis of the elbow joint. The treatment was well tolerated with no adverse reactions and was effective for up to one year in 50% of cases. 

Lattimer, J, Fabiani, M, Gaschen, L, Aulakh, K, Selting, K. Clinical effectiveness and safety of intraarticular administration of a ^117mTin radiocolloid (Synovetin OA^TM) for treatment of early and intermediate grade osteoarthritis of the elbow in a dose finding study conducted in 44 dogs. Vet Radiol Ultrasound. 2022; 1- 9. https://doi.org/10.1111/vru.13198 

Bottom line — One injection for pain control for up to 1 year

Just putting things in perspective …