Mg protects against cognitive decline ???

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Mg neuroprotective???

The study investigated the relationship between dietary magnesium intake, brain volumes, white matter lesions, and blood pressure to understand the potential neuroprotective effects of magnesium and its role in preventing neurodegeneration. The findings revealed that higher dietary magnesium intake was associated with larger brain volumes and lower white matter lesions, indicating better brain health. This association was observed in both cross-sectional analyses and when considering changes in magnesium intake over time. The neuroprotective effect of magnesium was particularly pronounced in grey matter and the hippocampus, which are crucial for cognitive functioning. However, contrary to the initial hypothesis, the study did not find a significant association between magnesium and blood pressure. Additionally, the study identified sex differences in the association between magnesium and brain health, with a more pronounced effect observed in women. The study acknowledges limitations such as the indirect measurement of magnesium intake and the inability to fully account for other influencing factors. Nonetheless, these findings provide valuable insights into the potential benefits of dietary magnesium in mitigating age-related neurodegeneration and may inform future interventions to promote brain health.

Alateeq, K., Walsh, E.I. & Cherbuin, N. Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences. Eur J Nutr (2023). https://doi.org/10.1007/s00394-023-03123-x 

Bottom line — Human study that probably applies to other species.

Thoughts on dosing telmisartan in dogs

This study aimed to establish the pharmacokinetic profile of telmisartan oral solution (TOS) in healthy adult dogs and determine the effect of feeding on its absorption. Telmisartan is a relatively new angiotensin II receptor blocking drug (ARB) used for treating various conditions in dogs, cats, and humans. The study found that TOS had a moderate terminal half-life and was rapidly absorbed in dogs, with a short Tmax in both fasted and fed states. However, there was high inter-individual variability in telmisartan disposition, posing potential challenges in recommending a universally effective dose. 

The results suggest that TOS can be administered with or without food in dogs, as long as it is done consistently for stable absorption. Further research is required to develop rational recommendations for telmisartan use in canine medicine. TOS may be beneficial for more accurate dosing in small dogs and for providing a liquid option for owners who have difficulty administering tablets or capsules. 

Bechtel, A. G., Reinhart, J. M., & Li, Z. (2023). Single-dose pharmacokinetics of telmisartan oral solution and effect of feeding in dogs. Journal of Veterinary Pharmacology and Therapeutics, 46, 17– 24. https://doi.org/10.1111/jvp.13104 

Bottom line — different kinetics. Aim for consistency.

Trazodone for cats

Cats are a popular pet but often face barriers to receiving proper veterinary care, including stress during transportation and at the clinic. "Stress-free" practices, such as oral sedatives and anxiolytics, are gaining popularity. Trazodone and gabapentin are two drugs commonly used for sedation and anxiety in veterinary medicine. Trazodone is a multifunctional drug with multiple therapeutic applications, including sedation and anxiolysis in cats, while gabapentin is mostly used as an anticonvulsant and analgesic to treat chronic and neuropathic pain. The objective of this study was to determine the pharmacokinetics and sedative effects of trazodone alone and in combination with gabapentin in healthy cats. The study found that oral trazodone administration at 5 mg/kg was safe and produced sedative effects lasting 6-8 hours post-administration. The combination of oral trazodone and gabapentin reduced the bioavailability of trazodone, but the sedative effect was not significantly different between the groups. Further research is needed to evaluate the sedative properties of these drugs alone or in combination with a larger sample size.

 Tucker, L. E., Sanchez, A., Valverde, A., Blois, S., Uccello, O., Rutherford, A., Monteith, G., Reinhart, J. M., Keating, S., Gu, Y., & Johnson, R. (2023). Pharmacokinetic, sedative, and physiological effects of oral compounded formulations of trazodone alone or in combination with gabapentin in male cats. Journal of Veterinary Pharmacology and Therapeutics, 00, 1– 11. https://doi.org/10.1111/jvp.13384 

Bottom line - can be used instead of gabapentin but no additive effect

Just putting things in perspective …

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